For US Healthcare Professionals
XARELTO®: Dosing for stroke risk reduction in nonvalvular atrial fibrillation (NVAF)
ONCE-DAILY DOSING* WITH 24-HOUR STROKE RISK REDUCTION1,2
*Taken with evening meal.
Tablets shown not actual size.
Renal Dosing Considerations
- Adjust XARELTO® dose based on renal function
- Periodically assess renal function as clinically indicated (ie, more frequently in situations in which renal function may decline) and adjust therapy accordingly
- Consider dose adjustment or discontinuation of XARELTO® in patients who develop acute renal failure while taking XARELTO®
| RENAL IMPAIRMENT (CrCl) | DOSAGE |
|---|---|
| Mild (>50-79 mL/min)1,3 | 20 mg QD* |
| Moderate (30-50 mL/min)1,3 | 15 mg QD* |
| Severe (15-29 mL/min)3 | 15 mg QD* |
AF = atrial fibrillation; CrCl = creatinine clearance; QD = once daily.