XARELTO®: Dosing for stroke risk reduction in patients with nonvalvular atrial fibrillation (NVAF)

ONCE-DAILY DOSING* WITH 24-HOUR STROKE RISK REDUCTION1,2

*Taken with evening meal.

No dose adjustment based on weight

20 mg

Once daily with the evening meal in patients with CrCl >50 mL/min

15 mg

MODERATE TO SEVERE RENAL IMPAIRMENT DOSE


Once daily with the evening meal in patients with CrCl ≤50 mL/min

Renal Dosing Considerations

  • Adjust XARELTO® dose based on renal function
  • Periodically assess renal function as clinically indicated (ie, more frequently in situations in which renal function may decline) and adjust therapy accordingly
  • Consider dose adjustment or discontinuation of XARELTO® in patients who develop acute renal failure while taking XARELTO®
  • See sections 2.1 and 8.6 of the Prescribing Information for additional information

For VTE prophylaxis in acutely ill medical patients at risk for thromboembolic complications who are not at high risk of bleeding.

CrCl = creatinine clearance; NVAF = nonvalvular atrial fibrillation; VTE = venous thromboembolism.