XARELTO®: Dosing in deep vein thrombosis (DVT) prophylaxis after hip or knee replacement surgery
DVT PROPHYLAXIS WITH ONCE-DAILY DOSING
10 mg
Once daily for 35 days, 6-10 hours after surgery once hemostasis has been established in patients with a CrCl ≥15 mL/min
10 mg
Once daily for 12 days, 6-10 hours after surgery once hemostasis has been established in patients with a CrCl ≥15 mL/min
Renal Dose Consideration
- Avoid using XARELTO® in patients with CrCl <15 mL/min
◇For VTE prophylaxis in acutely ill medical patients at risk for thromboembolic complications who are not at high risk of bleeding.
CrCl = creatinine clearance; DOAC = direct oral anticoagulant.