Condition-specific dosing for XARELTO®

20 mg

Once daily with the evening meal in patients with CrCl >50 mL/min

15 mg

MODERATE TO SEVERE RENAL IMPAIRMENT DOSE

Once daily with the evening meal in patients with CrCl ≤50 mL/min

2.5 mg

Twice daily with or without food in combination with aspirin (75 mg to 100 mg) once daily

 

No dose adjustment needed based on CrCl

 

15 mg

For the first 21 days, twice daily with food, at the same time each day in patients with a CrCl ≥30 mL/min

20 mg

Starting at day 22, once daily with food, at the same time each day for remaining treatment in patients with a CrCl ≥30 mL/min

15 mg

For the first 21 days, twice daily with food, at the same time each day in patients with a CrCl ≥30 mL/min

20 mg

Starting at day 22, once daily with food, at the same time each day for remaining treatment in patients with a CrCl ≥30 mL/min

10 mg

Once daily with or without food after ≥6 months of standard anticoagulant treatment in patients with a CrCl ≥30 mL/min

10 mg

Once daily for 35 days, 6-10 hours after surgery once hemostasis has been established in patients with a CrCl ≥30 mL/min

10 mg

Once daily for 12 days, 6-10 hours after surgery once hemostasis has been established in patients with a CrCl ≥30 mL/min

For VTE prophylaxis in acutely ill medical patients at risk for thromboembolic complications who are not at high risk of bleeding.

CAD = coronary artery disease; CrCl = creatinine clearance; CV = cardiovascular; DOAC = direct oral anticoagulant; DVT = deep vein thrombosis; NVAF = nonvalvular atrial fibrillation; PAD = pulmonary artery disease; PE = pulmonary embolism.