TREATMENT CONSIDERATIONS WHILE TAKING XARELTO®
Switching to or from XARELTO®
Stop warfarin and start XARELTO® when INR is <3.0
FROM UNFRACTIONATED HEPARIN
Stop the infusion and start XARELTO® at the same time
FROM OTHER ANTICOAGULANTS
Start XARELTO® 0 to 2 hours prior to the next scheduled evening administration of the other anticoagulant
One approach is to stop XARELTO® and start parenteral anticoagulant and warfarin at time of next scheduled XARELTO® dose
TO OTHER ANTICOAGULANTS†
Stop XARELTO® and start other anticoagulant when the next dose of XARELTO® would have been given
*No clinical trial data are available to guide converting patients from XARELTO® to warfarin. XARELTO® affects INR, so INR measurements made during coadministration with warfarin may not be useful for determining the appropriate dose of warfarin.
†Oral or parenteral rapid-onset anticoagulants.