XARELTO®: Dosing for stroke risk reduction in nonvalvular atrial fibrillation (NVAF)
ONCE-DAILY DOSING* WITH 24-HOUR STROKE RISK REDUCTION1,2
*Taken with evening meal.
Once daily with the evening meal in patients with CrCl >50 mL/min
MODERATE TO SEVERE RENAL IMPAIRMENT DOSE
Once daily with the evening meal in patients with CrCl ≤50 mL/min
Renal Dosing Considerations
- Adjust XARELTO® dose based on renal function
- Periodically assess renal function as clinically indicated (ie, more frequently in situations in which renal function may decline) and adjust therapy accordingly
- Consider dose adjustment or discontinuation of XARELTO® in patients who develop acute renal failure while taking XARELTO®
- See section 8.6 of the Prescribing Information for additional information
†Patients were considered at an increased risk for stroke if they had a higher CHADS2 score (range 1-6). Patients in ROCKET AF had a mean CHADS2 score of 3.5.
NVAF = nonvalvular atrial fibrillation; CrCl = creatinine clearance.