How does XARELTO® work?

XARELTO® is a selective inhibitor of FXa. It does not require a cofactor (such as anti-thrombin III) for activity. XARELTO® inhibits free FXa and prothrombinase activity. XARELTO® has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, XARELTO® decreases thrombin generation.

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◇For VTE prophylaxis in acutely ill medical patients at risk for thromboembolic complications who are not at high risk of bleeding.

FXa = Factor Xa; NSAID = nonsteroidal anti-inflammatory drug.