XARELTO®: Dosing for extended treatment and reduction in the risk of recurrence in deep vein thrombosis (DVT) and pulmonary embolism (PE)

Once daily for extended therapy after 6 months of initial treatment

10 mg

Once daily with or without food after 6 months of standard anticoagulant treatment in patients with CrCl 15 mL/min

Renal Dose Consideration*

  • Avoid using XARELTO® in patients with CrCl <15 mL/min

*Calculate CrCl based on actual weight.

Patients with CrCl <30 mL/min were not studied, but administration of XARELTO® is expected to result in serum concentrations of rivaroxaban similar to those in patients with moderate renal impairment (CrCl 30 mL/min to <50 mL/min).

The decision regarding initiation setting should be based on the prescriber's clinical judgment.

CrCl = creatinine clearance; DVT = deep vein thrombosis; PE = pulmonary embolism; VTE = venous thromboembolism.

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