How does XARELTO^® work?

XARELTO^® is a selective inhibitor of FXa. It does not require a cofactor (such as anti-thrombin III) for activity. XARELTO^® inhibits free FXa and prothrombinase activity. XARELTO^® has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, XARELTO^® decreases thrombin generation.