How does XARELTO® work?
XARELTO® is a selective inhibitor of FXa. It does not require a cofactor (such as anti-thrombin III) for activity. XARELTO® inhibits free FXa and prothrombinase activity. XARELTO® has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, XARELTO® decreases thrombin generation.
◇For VTE prophylaxis in acutely ill medical patients at risk for thromboembolic complications who are not at high risk of bleeding.
FXa = Factor Xa; NSAID = nonsteroidal anti-inflammatory drug.