Do I need to bridge patients with heparin or LMWH to XARELTO®?
There is no need to bridge with heparin or LMWH for the DVT and PE treatment indications. XARELTO® can be used as a single, oral agent at the time of diagnosis; it can also be used following initial treatment with heparin or LMWH.1,2
Initiation of XARELTO® is not recommended acutely as an alternative to unfractionated heparin in patients with PE who present with hemodynamic instability or who may receive thrombolysis or pulmonary embolectomy.
◇For VTE prophylaxis in acutely ill medical patients at risk for thromboembolic complications who are not at high risk of bleeding.
DVT = deep vein thrombosis; LMWH = low-molecular-weight heparin; PE = pulmonary embolism.