1. Dosing
  2. Dosing - DVT/PE Extended Treatment | XARELTO® (rivaroxaban)

XARELTO®: Dosing for extended treatment and reduction in the risk of recurrence in deep vein thrombosis (DVT) and pulmonary embolism (PE)

Once daily for extended therapy after 6 months of initial treatment

10 mg

Once daily with or without food after ≥6 months of standard anticoagulant treatment in patients with CrCl ≥15 mL/min

Renal Dose Consideration*†

  • Avoid using XARELTO® in patients with CrCl <15 mL/min

◇For VTE prophylaxis in acutely ill medical patients at risk for thromboembolic complications who are not at high risk of bleeding.

*Calculate CrCl based on actual weight.

†Patients with CrCl <30 mL/min were not studied, but administration of XARELTO® is expected to result in serum concentrations of rivaroxaban similar to those in patients with moderate renal impairment (CrCl 30 mL/min to <50 mL/min).

‡The decision regarding initiation setting should be based on the prescriber's clinical judgment.

CrCl = creatinine clearance; DVT = deep vein thrombosis; PE = pulmonary embolism; VTE = venous thromboembolism.